Changes in BQCA Allosteric Modulation of [3H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations
Changes in BQCA Allosteric Modulation of [3H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations
B. Dean,S. Hopper,P. J. Conn,E. Scarr
2016 · DOI: 10.1038/npp.2015.330
Neuropsychopharmacology · 31 Citations
TLDR
It is shown in vitro that BQCA, a positive allosteric CHRM1 modulator, brings about the expected change in affinity of theCHRM1 orthosteric site for acetylcholine in human cortex, and this effect is reduced in the cortex of a subset of subjects with schizophrenia.